December 6, 2017 1:00 pm JST

Indian biotech boom triggers surge in research startups

Big companies are outsourcing lucrative contracts to achieve cost savings

NIVEDITA NIRANJANKUMAR, Contributing writer

In less than a year, startup Cytxon Biosolutions has won about 50 contracts to perform research work for major biotech companies. (Photo by 101Reporters.com)

BANGALORE -- As a trained stem cell researcher Siddharth Dubey, 27, had an assured scientific career ahead of him. But Dubey, from India's northern Uttar Pradesh state, was quick to realize that the rapid growth of India's biotechnology industry was creating business opportunities for scientists.

In December 2016, Dubey and his business partner Joy Hoskeri co-founded Cytxon Biosolutions, a startup that provides major biotech companies with contract services covering research and development, drug discovery and preclinical studies.

Based in Hubbali, in Karnataka State, Cytxon has won about 50 contracts from companies such as India's Genei Laboratories, String Bio and Credora Life Sciences. It has monthly revenue of between 200,000 rupees ($3,100) and 300,000 rupees, and aims to reach 3 million rupees in revenues for the 12 months to December 2017. "That's how lucrative these biotechnology startups can be," Dubey said.

Cytxon, which has a team of five scientists, is one of many startups used by major biotech companies to conduct preproduction and postproduction work. Cost competitiveness and government assistance are helping to make India a global hub for outsourced biotech services.

The Biotechnology Industry Research Assistance Council, established by India's Department of Biotechnology, helps startups from the incubation stage to commercialization. The department has also set up a Biotechnology Ignition Grant, which offers funding up to $75,000 for scientists and entrepreneurs. In addition, there are state-specific policies to assist biotech startups.

The potential for startup clinical research organizations, known as CROs, exists "because there is significant cost advantage in what they are offering," said Pushpa Vijayaraghavan, a life sciences analyst and director of Sathguru Management Consultants in Hyderabad. "They can deliver the same service [for] one-tenth of the cost" charged by large CROs, she said.

A total of 1,022 biotech startups were launched in India between January 2012 and December 2016, with more than $2.8 billion in investment, according to the Association of Biotechnology Led Enterprises, a consortium of Indian biotech companies. The industry increased revenues by 57% to $11 billion in 2016, according to the India Brand Equity Foundation.

Most startups have landed contracts from major Indian companies -- including Cipla, Dr. Reddy's Laboratories and Sun Pharmaceutical Industries -- to do basic biochemical work, such as the study of enzymes and chemical reactions. But about 18% of contracts are research focused.

Big companies typically refuse to comment on their outsourcing policies, or to name CRO partners. But the trend can be identified in publications by the CROs. For example, ImageProVision Technology, a Pune-based startup specializing in processing detailed image analysis, lists Glenmark Pharmaceuticals, Aurobindo Pharma, Sun Pharma, Dr. Reddy's and Cipla among its clients.

Most startups offer a combination of services and products, helping bigger companies to save 20-30% on the cost of major projects.

"For a biotech company to undertake research work is not easy," Dubey said. "They have to spend a lot setting up a new facility, hiring the right people and also investing in all the raw material needed for research." Startups "already have the experts and the laboratories," he said.

"Once a contract is signed by the biotech major, the startup can begin work right away, and the client only needs to check from time to time," Dubey said. "The startups sometimes even take care of the regulatory processes needed for drug discovery."

Quality standards

India has long been a market for conducting research. Syngene International, founded in 1993 by Indian biotech pioneer Biocon, was one of the first clinical research organizations in the country.

Manoj Nerurkar, the company's chief operating officer, said that for most companies, setting up research infrastructure that meets global quality standards requires significant investment. Bringing in a CRO means not having to invest in recruiting a quality scientific talent pool.

Veena Rao, CEO of Vipragen, a startup founded in 2012 in Bangalore, said the drug-discovery environment has seen a surge of small companies. "Biotech companies need a strategic preclinical partner for performing discovery-driven, preclinical testing," she said. "Also, the ability to offer cost-effective and quality service is one of the contributing factors in starting a [contract research] service company."

Vipragen, which had revenues of 32 million rupees in the fiscal year ended March 2017, provides early-stage screening for safety and efficacy of drugs and chemicals before human use.

Smitha Murthy, founder and CEO of Bangalore-based Credora Life Sciences, said outsourcing benefits both big companies and startups. "For any company, the biggest cost is in setting up a laboratory with state-of-the-art technological equipment," said Murthy, whose company has awarded several projects to Cytxon. For startups, such investment is a one-off cost that can be spread across various projects.

The more difficult task for startups is to win contracts. While most large Indian CROs have teams in the San Francisco Bay area or other global innovation centers to engage with pharmaceutical clients, startups do not have that kind of presence, Vijayaraghavan said. To be successful, startup CROs need to invest in marketing and business development to attract global companies, or focus on a specialty field, she added.

Pandorum Technologies of Bangalore is one example. The developer of 3-D printed tissues has successfully created a functioning liver tissue. "It is not just supplying the functional tissue but a contract for all the research that goes into making it," said Arun Chandra, the company's co-founder.

Chandra said health care companies have begun asking Pandorum to make other body tissues. "In this way, while what we do can be termed as CRO work, we are still conducting research for our own product or project," he said.

Pandorum, which was founded in 2011, has yet to generate any revenues, having focused on research and development. However, Sachin and Binny Bansal, the co-founders of Flipkart, a large Indian online retailer, invested an undisclosed amount in the startup in 2016.

Dubey said all biotech startups in India are involved in some aspects of CRO services. "The initial grant offered by the government for any biotech startup is not more than 1 million rupees," he said.

"That amount, though good on paper, doesn't match the cost of buying equipment, setting up a laboratory, hiring people and then the most important cost of marketing your own product [or] drug," Dubey said.

"But if you do outsourced work for biotech giants, you are automatically set to make a profit."

Asia300

Cipla Ltd.

India

Market(Ticker): BOM(500087)
Sector:
Industry:
Health Technology
Pharmaceuticals: Other
Market cap(USD): 7,606.24M
Shares: 804.99M
Asia300

Dr. Reddy's Laboratories Ltd.

India

Market(Ticker): BOM(500124)
Sector:
Industry:
Health Technology
Pharmaceuticals: Generic
Market cap(USD): 6,404.81M
Shares: 165.82M
Asia300

Sun Pharmaceutical Industries Ltd.

India

Market(Ticker): BOM(524715)
Sector:
Industry:
Health Technology
Pharmaceuticals: Major
Market cap(USD): 21,657.18M
Shares: 2,399.24M

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